You can if you get it on PC and install mods to be able to.

It’s not farm sim, but Project Zomboid has some decent farming mechanics (and a shitload of mods). A lot of the very popular mods just add drugs into the game. A couple of those highest rated ones add a ton of weed stuff to the game (papers; grinders; bongs; pipes; farmable seeds and hemp with different strains, stages of growth, and even disease the plants can catch). Modders are wild.

Definitely. Can’t remember if it’s in the base game (update: no, it’s a mod) but it works like cotton and tobacco.