A bit of something new here, but we’ve known this for awhile. It’s not a viable long-term solution but if they’re talking the scope of just the treatment phase, maybe useful for some.
I’ll try and find the study, but this was almost the exact outcome of one done awhile back trying to find the correlation between patients with autoimmune diseases taking suppressants that had essentially no occurrences of malignant cancer over decades, but markers present. They found a strong correlation to regular DMARD doses and regular use of NSAIDs to be the cause. It makes your body essentially uninhabitable for cancer. Obviously, not everyone could/should be on such regimens throughout their life to prevent cancer lol.
It’s a little bit of good news for folks with autoimmune diseases. I’ve been reading a lot on spondyloarthritis / psoriasis over the last couple of weeks (being tested for both) and this doesn’t appear to be common knowledge.
Nope, it’s not common knowledge, and one study is certainly not bulletproof. The theory makes sense though. I wouldn’t bank that anyone is going to be telling people on these regimens they can’t get cancer, because most of those drugs cause cancer themselves. Double edged sword.
Cancer seems to be less of an issue with biologic DMARDs and with NSAIDs there are bigger cardiovascular issues to be worried about. But either way it’s trading bad outcomes.
My observation of online communities for chronic diseases is that there are some people that read new research papers and share new findings because there’s so little else they can do. Knowledge in those communities spreads fast (but so does bullshit unfortunately).
The study also sheds light on cancer’s strategy for hiding from defenses. Tumor cells increase the production of prostaglandin E2, a lipid substance that blocks the action of monocytes. At the same time, they decrease the production of interferons, proteins that stimulate the immune system. The Vienna group argues that anti-inflammatory drugs that inhibit cyclooxygenase, such as aspirin, are “a promising strategy” to increase the effectiveness of immunotherapy, since they block the production of inflammatory molecules, such as prostaglandin E2.
Interesting as aspirin, acetaminophen, and ibuprofen all inflame the gut to some degree, so although they reduce inflammation in the rest of the body your GI doesn’t react well.
Interesting trade off. Amazing development in understanding!
